InCoB 2014: Computational prediction of molecular mimicry in host-pathogen protein-protein interactions

Ranjeeta Menon, Nicolas Palopoli & Richard J. Edwards. F1000Research 2014, 5:1027 (poster)

Abstract

Many viruses hijack important cellular machinery of their hosts through the convergent evolution of host short linear motifs (SLiMs). We are combining host-pathogen and host-host protein-protein interaction data to explore such “molecular mimicry” across a broad range of human viruses. Computational tools from the SLiMSuite package are being used to assess the potential for bioinformatic analysis of high-throughput experiments to identify novel cases of molecular mimicry.